|
KMID : 0376219820190010001
|
|
Chonnam Medical Journal
1982 Volume.19 No. 1 p.1 ~ p.20
|
|
|
Studies on the roles of opiate receptors in the brain on the regulation of renal function.
|
|
ÏÓçµð÷/Kook, Y.J.
õËÜèÐ¥/ÛÜçµûø/Ë©á¢Ïþ/ÑÑýéФ/ÚÊíþãÕ/ðáïáÜå/Choi, B.K./Baik, Y.H./Kang, S.K./Kim, H.K./Min, J.S./Cho, J.B.
|
|
|
Abstract
|
|
|
Regulatory roles of the opiate receptors and endogenous morphine-like substances found in the brain on renal function were investigated in this study.
When introduced directly into a lateral ventricle of the rabbit brain, morphine as well as methionine- enkephalin( met-Enk) and leucine- enkephalin(leu-Enk) elicited antidiuresis which was brought about mainly by the decrements of renal plasma flow and glomerular filtration rate. The opioid peptides differed from morphine in that they tended to induce secondary increase in sodium excretion. However, the natriuresis and diuresis were not significant because of marked decrease in hemodynamics. In inducing antidiuresis morphine. was about 20 times more potent than the opioid peptides.
The antidiuresis induced by the agonists of opiate receptors was abolished. by cutting off the nerve connection to the kidney, indicating that no humoral agent was involved in the antidiuretic acton.
Nalorphine, a partial agonist-antagonist, induced antidiuresis, when given ivt, along with marked increase in free water reabsorption, suggesting the increased release of ADH, but the morphine effect was reversed by pretreatment of nalorphine. On the other hand, a pure antagonist naloxone produced no antidiuresis, but it elicited, in large doses, marked natriuresis and diuresis. And the antidiuretic actions of morphine, met-Enk and leu-Enk were completely abolished by the pretreatment of naloxone. These results are interpreted as. indicating that the antidiuresis induced by the opiate agonists are indeed mediated by the opiate receptors in the brain and that some endogenous opioid peptides or endorphmes -must have been.exertng _physiol 09, upon the kidney. through the opiate receptors in the brain.
It is evident from these observations that the opiate receptors an opioid ¢¥¢¥ substances endogenous in the brain play important roles in the regulation of renal function of the rabbit.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|